Collectively, there were an average of 2.3 (range 0–5) heterozygous loci in AD cases and 2.6 (range 0–6) heterozygous loci among the controls (S11 Table), providing 124 opportunities to discover allele-dependent ATAC-seq or NFKB1 peaks at AD genetic risk variants. This evidence concerns the gene NFKB1 and Alzheimer disease.