An important role for ΝF-κΒ in CD4+ T cells in AD was recently established using a mouse model of AD, in which mice injected with CD4+ T cells with inhibited ΝF-κΒ signaling showed marked improvement in AD-like skin lesions compared to those injected with CD4+ T cells with a control vector [20]. The gene discussed is CD4; the disease is Alzheimer disease.