NFKB1 and Alzheimer disease: Motif enrichment analysis in consistently AD- and control-specific peaks confirmed that NF-κB binding motifs were highly enriched in an AD-specific manner, with ~17% of consistently AD-specific peaks containing predicted NFKB binding sites (P < 10−13) compared to ~4% of consistently control-specific peaks (P = 1) (Fig 2C and 2D and S5 Table).