MEF2A and neurodevelopmental disorder: For example, OCRs that were more accessible in cortical PV+ neurons relative to striatal and GPe PV+ had enrichment for Mef2 family motifs, which are important in neuroplasticity (Donato et al., 2015), may play a role in specifying or maintaining the MGE PV+ neuron lineage in mouse and human (Mayer et al., 2018), and have been linked to neurodevelopmental disorders involving the prefrontal cortex (Mitchell et al., 2018).