TAAs are self-antigens that may be expressed in normal tissues but overexpressed in multiple types of cancers (e.g., survivin), expressed in specific tissues and cancers of those tissues (e.g., Melan-A in melanoma and melanocytes), or mainly expressed in cancer tissues and their genes are silenced in normal adult tissues (e.g., cancer-testis antigens) [72–74]. This evidence concerns the gene BIRC5 and cancer.