IL-1β (Interleukin-1β) protein was significantly increased by 330.6 % in AMD plasma compared to normal plasma: P = 0.0286; Normal plasma = 1 ± 0.3704 a.u.; AMD plasma = 4.306 ± 1.289 a.u. (Figure 4A). The gene discussed is IL1B; the disease is age-related macular degeneration.