Humanin G’s ability to reduce ICAM-1 protein is remarkable because targeted homozygous knockout of ICAM-1 gene in a laser injury-induced choroidal neovascularization (CNV) mouse model notably inhibited CNV as evidenced by substantially diminished volume of CNV lesions and decreased fluorescein leakage in ICAM-1 deficient mice compared to wild-type mice after laser photocoagulation injury [55]. Here, ICAM1 is linked to choroidal neovascularization.