We demonstrated that AMD plasma and AMD RPE cybrid cells had 186.1 % and 137.3 % higher protein levels of IFN-γ (Interferon-gamma), which is secreted by the T Helper Type 1 (Th1) cells and its activation is a hallmark of adaptive and innate immune responses [78, 79], IFN-γ causes RPE cell death by increasing intracellular iron concentration, oxidative stress, lipid peroxidation, glutathione depletion, and activation of the JAK-STAT signaling pathway [80]. Here, SOAT1 is linked to age-related macular degeneration.