Flavo decremented both levels in brain and heart homogenates in protected group compared with the Cyclo group, and this was in agreement with a study in which Flavo with dose (50, 100, 200 mg/kg; p.o.)in rat ischemic stroke model showed a significant decrease in TNF-α and IL-1β, and has a neuroprotective effect (Singh and Chopra 2014). This evidence concerns the gene IL1B and ischemic stroke.