TNF and Sepsis: This result is consistent with the work of Bitto et al. (2012) in which Flavo in a dose of 20 mg/kg improved pathological changes associated with sepsis in mice and apoptosis through inhibition of mitogen-activated protein kinases pathway, preserved β arrestin-2 expression, TNF-α, NF-κB, and increased IL-10 as well as lipoxin A4.