To further validate the association of purinergic signaling with cardiac inflammation and remodeling consequences resulted from sound pressure, we set myocardial infarction+noise insulation (NI), myocardial infarction+noise exposure (NI), and myocardial infarction+noise exposure+P2X3/7 inhibition (NE+P2X3/7 inhibition) group to evaluate elastic proteins collagen I (col-I), collagen III (col-III), NLRP3 protein, and cytokines IL-6, TNFα, TGFβ, IL-10. The gene discussed is P2RX3; the disease is myocardial infarction.