In contrast and consistent with the results in MVID due to MY05B deficiency, cystic fibrosis transmembrane conductance regulator (CFTR), which facilitates cyclic AMP-dependent chloride transport, showed comparable apical distribution in 2D organoid cultures derived from control and from UNC45A-deficient iPSC lines (Supplemental Figure 6D). The gene discussed is CFTR; the disease is microvillus inclusion disease.