Among these, the non-collagenous ECM protein decorin (DCN) was downregulated and fibrillin-1 (FBN1) was upregulated in individuals with lethal OI, whereas the cytoskeletal proteins palladin (PALLD1) and nestin (NES) were upregulated (Bini et al., 2021). This evidence concerns the gene DCN and osteogenesis imperfecta.