FBN1 and osteogenesis imperfecta: Among these, the non-collagenous ECM protein decorin (DCN) was downregulated and fibrillin-1 (FBN1) was upregulated in individuals with lethal OI, whereas the cytoskeletal proteins palladin (PALLD1) and nestin (NES) were upregulated (Bini et al., 2021).