To further evaluate the potential role of pyroptosis‐related genes in predicting survival status of HNSCC patients, we conducted Cox regression and LASSO analysis, and identified seven‐gene signature (CASP1, GSDME, IL6, NLRP1, NLRP2, NLRP6, and NOD2) and built a HNSCC risk model. Here, NLRP6 is linked to head and neck squamous cell carcinoma.