To further evaluate the potential role of pyroptosis‐related genes in predicting survival status of HNSCC patients, we conducted Cox regression and LASSO analysis, and identified seven‐gene signature (CASP1, GSDME, IL6, NLRP1, NLRP2, NLRP6, and NOD2) and built a HNSCC risk model. This evidence concerns the gene NLRP2 and head and neck squamous cell carcinoma.