In this work, we investigated the expression and intracellular localization of SIRT1 and SIRT2 in neurons and astrocytes of the peri-infarct area on the first day after photothrombotic stroke (PTS), as well as the effect of selective SIRT1 and SIRT2 inhibitors on the apoptosis and the damage volume in the peri-infarct area after PTS. This evidence concerns the gene SIRT1 and Stroke.