Regarding its role in cardiovascular diseases (CVDs) and neurobiology, previous studies provided evidence that SIRT1 reduction links vascular senescence and inflammation to abdominal aortic aneurysms (AAA) and that SIRT1 in vascular smooth muscle cells provides a therapeutic target for the prevention of AAA formation (Chen et al., 2016). The gene discussed is SIRT1; the disease is triple-A syndrome.