SIRT1 and ischemia: In addition, it is known that SIRT1 deacetylates its downstream targets, including NF-κB, Foxos, p53, PGC-1α, HIF, UCP, etc., in order to regulate the processes of oxidative stress, apoptosis, and inflammation during ischemia, both in the nuclei and in the cytoplasm of neurocytes (Meng et al., 2017; Yan et al., 2019).