FOXO3 and ischemic stroke: SIRT1 activity suppresses FoxO3a during ischemic stroke, which leads to the suppression of several proapoptotic factors such as p53, TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), Bcl-2-like protein11 (Bim), and activation of genes for antioxidant defense enzymes catalase and mitochondrial manganese-dependent superoxide dismutase (MnSOD), which protects neurons from apoptosis (She et al., 2017).