In addition to NPAS2, loss of function or decreased expression of other molecular clock proteins in the NAc (e.g., CLOCK, PER, CRY, and REV-ERBα) have also been shown to directly alter a whole range of behaviors, including reward, anxiety, cognitive function, stress-susceptibility, mood and depressive-like behaviors (De Bundel et al., 2013; Spencer et al., 2013; Landgraf et al., 2016a; Parekh et al., 2018; Zhao and Gammie, 2018; Porcu et al., 2020). The gene discussed is CLOCK; the disease is Anxiety.