We previously showed that diet-induced obesity in mice increased AHR in association with increased IL-1β gene expression in the lung (Younas et al., 2019) (Fricke et al., 2018) and IL-1β receptor blockade by anakinra prevented obesity-induced AHR (Younas et al., 2019), suggesting a mechanistic role of IL-1β in obese asthma. The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.