OCLN and colorectal cancer: Colorectal cancer cells secreted exosome miR-25-3p, which targeted vascular endothelial growth factor (VEGF) receptor 2, zonula occludens 1, occludin, and claudin five on endothelial cells to induce vascular permeability and angiogenesis, forming a premetastatic niche for colorectal cancer metastasis (Zeng et al., 2018a).