In 6-month-old KC pancreata (n = 7 mice), metaplastic ducts were found to contain a significantly higher proportion of SYP+ cells as compared to PanIN1a lesions (10.76%, n = 105 vs 6.35%, n = 302; p < 0.001) (Figures 3A,C and Supplementary File S1). This evidence concerns the gene SYP and keratoconus.