GHRL and keratoconus: 374 and 296 lesions from 6 and 12-month-old KC mice (n = 7 and n = 5, respectively) were analyzed, and metaplastic ducts contained a significantly higher proportion of GHRL+ positive cells (4.34%, n = 122) as compared to PanIN1a (2.00%, n = 517; p < 0.001) and PanIN1b (1.00%, n = 18; p < 0.005) (Figure 5B and Supplementary File S1).