Interestingly, we found that SYP+ cells are significantly more abundant in metaplasia in KC mice than in KPC mice (9.36%, n = 163 vs 7.72%, n = 301; p < 0.05), although SYP+ cells are more abundant in KPC pancreata later in disease progression (Supplementary Figure S2B). This evidence concerns the gene SYP and keratoconus.