ERBB2 and breast cancer: Specifically, 47 samples scored up to but no higher than HER2 2+ according to the BC/GEA criteria was scored up to but no higher than 1+ according to the HERACLES criteria; 3 samples scored up to HER2 3+ according to the BC/GEA criteria was scored up to but not higher than 2+ according to the HERACLES criteria (Figure 1B).