In 2011, Karli Rosner suggested an anti-cancer therapeutic approach based on human recombinant DNAse I. According to his approach, the replacement of apoptosis-activated endogenous DNAses with human recombinant DNAse I might help to bypass cancer defense mechanisms, increasing the killing efficiency of chemo and radiotherapy-resistant tumor cells (268). Here, DNASE1L3 is linked to neoplasm.