The normal human body sustains intestinal injury when absorbing fat, which is repaired after 50 min (88), while long-term excessive fat intake can activate mast cells in the intestinal mucosa, cause them to secrete TNF-α, IL-1β, IL-4 and IL-13 and other regulatory factors, and indirectly increase intestinal cell permeability, which allows more LPS to penetrate the blood (especially through intercellular infiltration), causes endotoxemia and stimulates the inflammatory response. This evidence concerns the gene TNF and serum lipopolysaccharide activity.