EGFR and cancer: The mechanism may be inhibition of cancer cells by the activation of the apoptotic gene bax, which activates the activity of basic spatholinase (8mase) and caspase-3 (caspase-3), inhibiting the mutation of k-ras and the expression of ras-dependent cox-2, and inhibiting the activation of erk, fra-1 and epidermal growth factor receptor (egfr) caused by DCA.