CYC1 and breast cancer: By performing the LASSO Cox regression analysis with 9 candidate genes in breast cancer patients of TCGA-BRCA training dataset, 5 pivotal genes were unearthed to establish the prognostic signature, Lactate Metabolism Index, namely LMI (Figures 2A, B), including RPS14, SLC19A1, CYC1, RRM2B, OCRL.