RHD and neoplasm: Our results show that in vitro blockade of the NOTCH pathway using the γ-secretase inhibitor PF-03084014 (PF-0308), investigated in clinical trials on other tumor types, resulted in the up-regulation of total and phosphorylated MET protein levels in both the FP-RMS RH30 and RH4 and the FN-RMS RD and JR1 cell lines.