Concomitantly, the FcεRI-induced activation of ADMC induced significant downregulation of several genes shown to be markedly upregulated in certain cancers and metastasis including cystatin 4 (CST4), secretagogin (SCGN), calcitonin receptor (CALCR), hairy and enhancer-of-split related with YRPW motif (HEY2), and the leucine-rich-repeat-containing G protein-coupled receptor 6 (LGR6) (25–30) (Figure 4B). This evidence concerns the gene LGR6 and cancer.