IGHE and neoplasm: While the contribution of MCs in studies examining the anti-tumor effects of IgE have been largely overlooked, it is highly plausible that the IgE Fc binding to MC-FcεRI mediates the anti-tumor effects given the affinity of this interaction (16), the juxtaposition of MCs to tumor cells (17), and the anti-tumor mediators within MCs that are released by the interaction of IgE with tumor antigens (10, 18).