found that CircMMP1 was abnormally up-regulated in glioma tissues and serum exosomes compared with corresponding counterparts, and CircMMP1 promoted the proliferation and motility and impeded the apoptosis of glioma cells by enhanced high mobility group box 3 (HMGB3) level through sponging miR-433 (61). Here, HMGB3 is linked to central nervous system cancer.