Co-culture of DC-Ad-SP17 with autologous lymphocytes induces high frequencies of IFNc+ and CD8+ CTLs, which have selective cytotoxicity against SP17+ lung cancer CRL-5922 cells in an HLA-I restrictive manner, suggesting that SP17-overexpression induces antigen-specific anti-tumour immunity against SP17+ NSCLC. This evidence concerns the gene CD8A and neoplasm.