In p53 mutant-type GBM cells, PELATON inhibits the production of ROS, reduces the levels of divalent iron ions, promotes the expression of SLC7A11, and inhibits the expression of ACSL4 and COX2. GBM cells with PELATON knockdown showed smaller mitochondria, increased mitochondrial membrane density, and decreased mitochondrial cristae. Here, PELATON is linked to glioblastoma.