RYR2 and glioblastoma: To identify which is likely the most important molecule of ROS biosynthesis involved in the ferroptosis suppressor PELATON, we analysed the top 20 genes that are differentially expressed between GBM and normal brain tissue (Figure 3B) and then wanted to determine which of these is most commonly mutated or overexpressed in human GBM, which revealed P53, RYR2 and IDH1 at the top of this analysis, with a mutation rate of p53 up to 30% (Figure 3C).