In wild-type p53 primary cultured GBM PG-1 cells, PELATON inhibited the expression of BACH1 and CD44 (Supplementary Figures 3F, H), but PELATON had no effect on the expression of GPX4, BACH1 and CD44 in the p53 mutant GBM cells, such as PG-3 and PG-2 (Figures 3D–G and Supplementary Figures 3G, I), suggesting that the mutant site of P53 may affect the binding of P53 and target genes. This evidence concerns the gene CD44 and glioblastoma.