In conclusion, we confirmed that PELATON is a new ferroptosis suppressor and an oncogene and established a prognostic model and diagram of ferroptosis in GBM patients with NCOA4 and PELATON, provided that PELATON alleviates ferroptosis driven by wild-type or mutant p53 and suppresses wild-type or mutant p53-mediated GBM proliferation. The gene discussed is TP53; the disease is glioblastoma.