(45) showed that sirtuin 2 (SIRT2) inhibits hypoxia-induced VEGF-D synthesis in head and neck cancer (HNC) cells, and expression of SIRT2 was significantly linked to VEGF-D expression and lymphangiogenesis in HNC tissue, where a substantial fraction of SIRT2 protein was produced at a lower level. The gene discussed is SIRT2; the disease is head and neck cancer.