Despite the fact that lymphatic spread is an important event in the progression of HNSCC, the levels of VEGF-C, VEGF-D, and VEGFR-3 are not related to the clinicopathological characteristics reported in other studies, suggesting that lymphangiogenesis in HNSCC is mediated by other signaling pathways (46). Here, FLT4 is linked to head and neck squamous cell carcinoma.