VEGFA and neoplasm: In addition, VEGF-A has been shown to induce lymphangiogenesis and SLN metastasis of OSCC cells in vitro, and 3-O-acetyloleanolic acid (3AOA) has been shown to inhibit tumor growth, tumor-induced lymphangiogenesis, and SLN metastasis in a VEGF-A-induced oral cancer sentinel lymph node (OCSLN) animal model created with high expression of VEGF-A in squamous cell carcinoma (SCCVII) cells (26).