METTL3 and chronic myelogenous leukemia, BCR-ABL1 positive: The m6A methyltransferase complex METTL3/METTL14 and METTL3 is upregulated in primary CML patients, and its downregulation significantly impairs the proliferation of both primary CML cells and TKI-sensitive and TKI-resistant CML cells (60).