As such, we herein assessed the ability of ECM1 to affect the migratory and invasive activity of CRC cells via this signaling pathway, revealing that ECM knockdown was associated with decreases in p-AKT, p-GSK3β, and Snail expression in CRC cells, whereas ECM overexpression yielded the opposite outcome. The gene discussed is GSK3B; the disease is colorectal carcinoma.