In line with these results, we observed ECM1 upregulation in CRC tumor cells relative to colonic epithelial cells at the mRNA and protein levels, and found that the overexpression of ECM1 was associated with enhanced CRC cell proliferative activity in CCK-8 and colony formation assays, whereas knocking down ECM1 yielded the opposite phenotypes. This evidence concerns the gene ECM1 and neoplasm.