It was found that LECT2, SEMA4F, EPO, CHGA, NR0B1, S100A9, CCR3, and SPP1 were low expressed in human hepatoma cells compared with normal human hepatic epithelial cells (Unpaired t-test, p<0.01) (Figure 8). The gene discussed is SEMA4F; the disease is hepatocellular carcinoma.