The results revealed that effector memory CD8 T cells (P = 0.00617), NK cells (P = 0.0147), neutrophils (P = 2.02e-05) and other cells were highly correlated with METTL3 expression (Figure 3E), indicating that the METTL3 gene could have a crucial impact on the cellular immune regulation process of ESCC. The gene discussed is CD8A; the disease is esophageal squamous cell carcinoma.