METTL3 expression was considerably higher in liver cancer, cholangiocarcinoma, colon cancer, and other tumor tissues than in normal tissues (*P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001; -, not significant, Figure 1A). This evidence concerns the gene METTL3 and malignant colon neoplasm.