BCL2 and neoplasm: In this case, dual inhibition of the driver oncogene and its downstream target (e.g., anti-apoptotic proteins of the Bcl-2 family), which is required for survival of tumor cells under oncogene-related stress (e.g., oxidative, replicative, metabolic, etc.)or in response to inhibition of the primary target, could yield a synergistic effect in both sensitive and resistant cells (98).