For example, CML with overexpression and activation of other kinases (e.g., the Src family kinases such as Lyn, Hck, and Fyn) at downstream signaling cascade of BCR-ABL signaling are likely resistant to TKIs directed against BCR-ABL (99). The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.