As a key family of anti-apoptotic proteins, Bcl-2 or its relatives (e.g., Bcl-xL and Mcl-1) are highly expressed in various types of cancer, particularly hematologic malignancies (e.g., lymphoma, leukemia, and multiple myeloma/MM), therefore representing one of the most attractive therapeutic targets (37, 38). Here, BCL2 is linked to Miyoshi myopathy.