This study presented that three SNPs in two MMPs had no association with two cancers in any genetic model and/or ethnicity; of these, one SNP showed no relation with the risk of cancer (MMP-2 rs243865 with BC) in meta-analyses that involved at least 2,000 cases and 2,000 controls, providing >85% power for detecting OR = 1.15 in the allelic model for the variant with type 1 error 0.05 and minor allelic frequency (MAF) 0.20 (Supplementary Tables S3, S4). This evidence concerns the gene MMP2 and breast cancer.