AFP and neoplasm: When the time horizon was set at to 10 years, the relevant role of AFP slope was confirmed (OR = 4.95; P < 0.0001), followed by microvascular (OR = 2.13; P < 0.0001) and macrovascular invasion (OR = 2.32; P = 0.01), poor tumor grading (OR = 1.95; P = 0.001), total number of neo-adjuvant therapies (OR = 1.11; P = 0.001), and diameter of the target lesion (OR = 1.11; P = 0.002).