As for the risk of 5-year HCC-specific death, AFP slope had the highest OR of 4.50 (P < 0.0001), followed by microvascular invasion (OR = 2.02; P = 0.001), macrovascular invasion (OR = 2.82; P = 0.003), diameter of the target lesion (OR = 1.11; P = 0.004), poor grading (OR = 1.80; P = 0.007), and number of nodules (OR = 1.07; P = 0.009). This evidence concerns the gene AFP and hepatocellular carcinoma.