Overall, COMMD2 expression was upregulated in BLCA, CHOL, COAD, ESCA, GBM, HNSC, LIHC, LUSC and STAD tissues and downregulated in KICH, LUAD, PRAD and THCA tissues, indicating that COMMD2 may crucially regulate carcinogenesis in these 13 types of cancer. Here, COMMD2 is linked to cancer.