Regarding the different tumor stages, upregulation of COMMD2 expression was associated with the a poor OS of patients with LIHC classified as stage 1 + 2, stage 2, and stage 2 + 3. A significant correlation between COMMD2 expression and a poor OS was observed in patients with American Joint Committee on Cancer (AJCC) stage T-2 and grade 2 LIHC. This evidence concerns the gene COMMD2 and neoplasm.