To further understand the relationship between Spike S1+ EVs and other significantly altered factors between healthy controls and COVID‐19 patients, we performed direct correlation analysis between the levels of Spike S1+ EVs and Spike S1+CD31+ EVs, viral specific immunoglobulins (IgG1 and IgG3) and immunosuppressive IL‐10 (Figure 3E). This evidence concerns the gene PECAM1 and COVID-19.