CHMP5 and COVID-19: Two of the Spike S1+ EVs positive patients at day 10 showed elevated levels of SARS‐CoV‐2 specific IgA and IgG (up to 24 and 3 G/l, respectively) which are predominantly observed in severe COVID‐19 cases, suggesting the dynamics Spike S1+ EVs levels in patients could provide sensitive detection of alternated immunological responses.