Another negative correlation was observed between Spike S1+ EVs and immunosuppressive IL‐10, suggesting patients with higher Spike S1+ EVs are less prone to severe complications such as acute respiratory distress syndrome and secondary hemophagocytic lymphohistiocytosis (Dhar et al., 2020; Han et al., 2020; Lu et al., 2021). The gene discussed is IL10; the disease is acute respiratory distress syndrome.