Negative correlation between Spike S1+ EVs and generic viral induced IgG1 and IgG3 responses (Vidarsson et al., 2014) implies that Spike S1+ EVs levels could indicate the chances of developing SARS‐CoV‐2 specific responses in an early predictive manner as well as other post‐COVID‐19 conditions such as PACS as suggested by a recent multicentric cohort study of 212 individuals (Cervia et al., 2021), and subsequently, enable more precise and prompt treatment decision in the clinics. Here, IGHG3 is linked to COVID-19.