From this work, they concluded that PLCγ1 represents a critical downstream pathway for ZNF198-FGFR1-induced disease, and that Grb2 activation was important for BCR-FGFR1 in the induction of CML-like leukemia in mice [10]. This evidence concerns the gene GRB2 and chronic myelogenous leukemia, BCR-ABL1 positive.