For example, it’s plausible that greater proportions of functionally-beneficial adipocytes such as adiponectin producing/insulin sensitive, and/or thermogenic adipocytes, may be expected to not only positively affect whole-body metabolic state cross-sectionally, but to also predict lower risk of developing obesity co-morbidities. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.