- Greater total subcutaneous adipose fibrosis adjusted for age, diabetes and circulating IL-6 was associated with a low weight loss response (i.e., <25% decrease in BMI). (n=243 persons with obesity, OR [95% CI] = 1.58 [1.10-2.28]). The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.