There was a significant difference in the number of carriers between the groups of children with and without obesity [p=0.0107 (0.0014-0.0553); median (IQR) of p-values distribution] for the LEPR gene, where 21 VUS and 2 DCVs were identified [BMI SDS=2.8 (0.6); median (IQR)]. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.