2 VUS and 2 compound VUS, identified in the POMC gene, did not cause a detectable difference in the number of carriers with and without obesity [BMI SDS=1.8 (1.6)], but 5 identified heterozygous DCVs in the POMC gene were identified in participants with excess body weight [BMI SDS=3.3 (0.5)] and none in participants without obesity. This evidence concerns the gene POMC and obesity disorder.