Several genes associated with development of depressive disorders were upregulated in adult brain following developmental exposure to FLX only in the unstressed condition; e.g., nr3c2 (unstr-FLX-Hyp: FC= 3.12, p= 2E0-5; unstr-FLX-Tel: FC= 1.6, p= 0.01), clocka (unstr-FLX-Hyp: FC= 2, p= 2E0-6; unstr-FLX-Tel: FC= 1.4, p= 0.03), grm3 (unstr-FLX-Hyp: FC= 2.3, p= 5E0-6; unstr-FLX-Tel: FC= 1.8, p= 0.02), and ntrk2a (unstr-FLX-Hyp: FC= 1.7, p= 3E0-12; unstr-FLX-Tel: FC= 1.4, p= 0.006). The gene discussed is GRM3; the disease is depressive disorder.