CCR5 inhibition of premotor cortical neurons has no significant effect on microglia responsiveness, but 2 months after ischemia, mice with complete CCR5 deletion in the brain have fewer long-term inflammatory cells, such as Iba1+ cell infiltration around the peri-infarct tissues (Sorce et al., 2010; Ping et al., 2021). This evidence concerns the gene CCR5 and ischemia.