Inhibition of CCR5 expression in premotor cortical neurons after stroke can modulate astrogliosis, reduce astrocyte reactivity, and dampen macrophage recruitment; this inhibition as an intervention can help create a conducive environment for neural repair (Adelson et al., 2012; Barreto et al., 2012; Liraz-Zaltsman et al., 2021). This evidence concerns the gene CCR5 and stroke disorder.