A recent study found CCR5 activation after intracerebral hemorrhage, partially through the CCR5/PKA/CREB/NLRP1 (nucleotide-binding domain leucine-rich repeat pyrin domain containing 1) signaling pathway, promoted neuronal pyroptosis, and neurological deficits (Yan et al., 2021). Here, CCR5 is linked to intracerebral hemorrhage.