These include tau in tauopathies, α-synuclein in synucleinopathies, such as Parkinson’s disease (PD), TDP-43 in frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), huntingtin in Hungtinton’s disease (HD) and amyloid beta (Aβ) in Alzheimer’s disease (AD) (Ross and Poirier, 2004). Here, MAPT is linked to Alzheimer disease.