MAPT and Alzheimer disease: For example, upregulated MMP-3 levels were found in the cortex of AD-like amyloidosis transgenic rat models (Pentz et al., 2021), and the concentration of MMP-3 and levels of total and phosphorylated tau positively correlate in the cerebrospinal fluid (CSF) of AD patients (Stomrud et al., 2010; Hanzel et al., 2014).