TARDBP and amyotrophic lateral sclerosis: Several TDP-43 fragments have been observed in human samples from ALS-FTD patients (Smethurst et al., 2016) and C-terminal fragments appear to retain aggregation properties (Igaz et al., 2009; Nonaka et al., 2009; Furukawa et al., 2011; Shimonaka et al., 2016).