TF and biological process involved in symbiotic interaction: Taken together, our findings underline a plausible tendency of clinical isolates of Leishmania from TF patients to modulate the gene expression of some host-cholesterol genes that lead to a signaling response, thereby modifying the immune response required to control the progression and evolution of this parasite infection and contributing to immune evasion of the parasites and TF in patients with leishmaniasis.