MTHFD2 and head and neck squamous cell carcinoma: More specifically, in patients with HNSCC, the expression levels of CCT6A, CORO1A, CYB5B, GAPDH, HPRT1, HSPA5, MTHFD2, P4HA1, PGK1, PLOD2, PSMB5, PSMD14, RDH11, SEC11A, SLC2A3, SQLE, STC1, STIP1, TRIB3, and UFM1 were higher in tumors than in normal tissues, whereas ELOVL6 and ME1 were more highly expressed in normal tissues than in tumors (Figure 4A, p < 0.01).