The results of the K–M survival analysis demonstrated that all identified genes had a major impact on the clinical outcome of patients with HNSCC in TCGA database (SEC11A: p < 0.001; SC5D: p < 0.001; CYB5B: p = 0.005; HPRT1: p = 0.006; SLC2A3: p = 0.007; CORO1A: p = 0.003; PIK3R3: p = 0.005). The gene discussed is CYB5B; the disease is head and neck squamous cell carcinoma.