TRPM7 and obesity due to melanocortin 4 receptor deficiency: Therefore, TRPM7 channels may be up-regulated when plasma levels are increased in vivo due to obesity, and we speculated that when this event occurs in adrenal chromaffin cells, more Ca2+ influx due to up-regulation of TRPM7 channels may induce increased catecholamine secretion, which is likely to be one of the reasons associated with hypertension.