In addition to being activated by their activators, TRPM2, TRPM4, and TRPM5 can also be triggered by the influx of Ca2+ to participate in membrane depolarization, and TRPM2, TRPM7, and TRPM8 are involved in the progression of pancreatic adenocarcinoma (Islam, 2011; Uchida and Tominaga, 2011; Yee et al., 2012a; Uchida et al., 2017; Islam, 2020). The gene discussed is TRPM8; the disease is pancreatic adenocarcinoma.