These fifteen nsSNPs (P572L, M546V, I721N, F610S, A732T, F51S, A717D, E722K, R57H, R109W, R191H, S532C, G192S, F529L, and H804Q) have not yet been connected to TCIRG1 gene-related osteopetrosis and congenital neutropenia, however, they could be utilized as a markers nsSNPs variants whenever diagnosing disorders related with TCIRG1 gene. The gene discussed is TCIRG1; the disease is severe congenital neutropenia.