Therefore, we used the TCGA, Genotype-Tissue Expression (GTEx), and other databases to conduct a specific pan-cancer analysis of CASP3. In addition to CASP3 expression in different tumours and its prognostic implications, our analysis included gene mutations, methylation, tumour mutational burden (TMB), microsatellite instability (MSI), and potential associations of CASP3 in 33 tumour types. The gene discussed is CASP3; the disease is neoplasm.