Four lncRNAs in the network (CRNDE, DLEU1, LEF1-AS1, and LINC01616) were significantly associated with overall survival of GBM patients (Supplementary Figure S2) and were involved mainly in regulating the cell cycle, mitosis, leukocyte activation during immune responses, and DNA replication (Figure 5C). This evidence concerns the gene LEF1 and glioblastoma.