Sumoylation of vimentin by Protein Inhibitor of Activated STAT3 (PIAS3) inhibits glioma cell migration (Wang et al., 2010) while acetylation of vimentin intermediate filaments at K120 b SIRT5 increases metastasis in hepatocellular carcinoma (Guo et al., 2018). The gene discussed is VIM; the disease is central nervous system cancer.