PIK3R3 and hepatocellular carcinoma: The HOXD-AS1/miR-186-5p/PIK3R3 is a novel route in epithelial ovarian cancer that promotes cell migration, invasion, and epithelial-mesenchymal transition (EMT) (Dong et al., 2019); hence, circ-PRKCI may also boost the survival, invasion, and migration of HCC cells by sponging miR-186-5p to increase FOXK1 expression levels (Chen et al., 2021).