While either SOX11 or ZIC1 promotes the expression of TUBB3/βIII-tubulin and induces a neuronal phenotype in U87 glioblastoma cells, the expression of ZIC1 greatly enhances the impact SOX11 has on TUBB3 expression and neuronal differentiation (Fu et al., 2019). Here, SOX11 is linked to glioblastoma.