The loss of REST in a range of cancers has also been linked to the aberrant expression of neuronal genes in the clinic, including TUBB3. A negative correlation between REST and TUBB3 expression has been reported in skin, ovarian, and small cell lung cancer biopsy samples (Akasaka et al., 2009; Kreisler et al., 2010; Hatano et al., 2011; Gao et al., 2012), while in normal non-neoplastic tissues TUBB3 is barely detectable. This evidence concerns the gene REST and small cell lung carcinoma.