Induction of TUBB3 expression has been widely reported in numerous cancer cell lines by both short term (Ranganathan et al., 1998b) and long term (Ranganathan et al., 1996; Kavallaris et al., 1997; Ranganathan et al., 1998a; Ranganathan et al., 1998b; Shalli et al., 2005) exposure to TBAs, a class of chemotherapeutics that target tubulin and microtubule dynamics (reviewed in Jordan and Wilson, 2004; La Regina et al., 2019). The gene discussed is TUBB3; the disease is cancer.