TUBB3 and neoplasm: Since other neuronal differentiation factors mentioned previously are also linked to this altered TUBB3 expression (Castillo et al., 2012; Raspaglio et al., 2014; Namekawa et al., 2020), it poses the question—are dysregulated processes associated with neuronal gene regulation the primary causes of aberrant TUBB3 expression in tumours of non-neuronal origin?