TUBB3 and neoplasm: Of note, one particular isotype, βIII-tubulin, encoded by the TUBB3 gene, has demonstrated aberrant expression in the clinical setting, and has been identified as a marker of drug resistance and tumour aggressiveness in a sub-set of epithelial cancers (reviewed in Kavallaris, 2010; Karki et al., 2013; Mariani et al., 2015).