For example, in ovarian cancer cells, DNA demethylation CpG island (containing 86 CpGs) within TUBB3 intron 1 has been shown to result in βIII-tubulin overexpression, with chromatin acetylation accelerating the process and increasing TUBB3 expression as well (Izutsu et al., 2008; Akasaka et al., 2009). The gene discussed is TUBB3; the disease is ovarian carcinoma.