TUBB3 and neoplasm: In tumours, the hypoxia-inducing factor HIF1α has been implicated in the transcriptional regulation of βIII-tubulin via the 3′UTR of the TUBB3 gene and is thought to protect tumours against hypoxic injury (Raspaglio et al., 2008; Forde et al., 2010; Danza et al., 2012; Bordji et al., 2014; Raspaglio et al., 2014).