CDKN2A and lung cancer: KRAS mutant lung adenocarcinoma is often associated with a mutation in CDKN2A or LKB1. Mouse models of lung cancer typically use three different genotypes to recapitulate LUAD; Kras;Tp53 (KP), Kras;Cdkn2a (KC), and Kras;Lkb1 (KL).