As noted previously, ALS-associated variants in ANXA11 have been shown to disrupt RNA granule-lysosome docking, impeding their transport in neurons (Liao et al., 2019) and ANXA11 mutants can impede calcium homeostasis and stress granule disassembly (Nahm et al., 2020). This evidence concerns the gene ANXA11 and amyotrophic lateral sclerosis.