Cyclin F, encoded by CCNF gene, is one of the components of an E3 ubiquitin-protein ligase complex and ALS/FTD-associated mutations have been found to impair autophagosome-lysosome fusion through direct binding and increased ubiquitylation of p62/SQSTM1 (Lee et al., 2018). This evidence concerns the gene SQSTM1 and amyotrophic lateral sclerosis.