Investigation of the C9orf72 arginine-rich DPR interactomes found a wide number of RBPs and were enriched in those involved in membraneless organelles including SGs components and major ALS/FTD RBP proteins, such as TDP-43 and hnRNPA1 (Lee K.-H et al., 2016; Boeynaems et al., 2017; Chew et al., 2019). This evidence concerns the gene HNRNPA1 and amyotrophic lateral sclerosis.