The ALS-associated autophagy receptor p62 is recruited to SGs upon cellular stress (Chitiprolu et al., 2018; Turakhiya et al., 2018); TBK1 (TANK-binding kinase 1; (Cirulli et al., 2015; Freischmidt et al., 2015)) phosphorylates p62 (Pilli et al., 2012; Matsumoto et al., 2015) and another autophagy receptor - optineurin (Matsumoto et al., 2015), which enhances affinity to cargo and promotes selective autophagy of damaged mitochondria or intracellular pathogens (Richter et al., 2016). Here, OPTN is linked to amyotrophic lateral sclerosis.