Indeed, several pathogenic variants in genes encoding vesicular transport machinery proteins, such as PFN1(profilin) (Chen et al., 2013; Ingre et al., 2013), TUBA4A (tubulin isotype α4a) (Smith et al., 2014), KIF5A (kinesin family member 5A) (Nicolas et al., 2018) and DCTN1(dynactin subunit 1) (Münch et al., 2004), in addition to the cytoskeleton component SPG11 (spatacsin) (Orlacchio et al., 2010), are directly associated to ALS. The gene discussed is KIF5A; the disease is amyotrophic lateral sclerosis.