Although in most cases, studies have not investigated a direct link between granulophagy and ALS/FTD associated autophagy genes, disease associated mutations in VCP (Gitcho et al., 2009; Johnson et al., 2010) have been shown to induce persistent SGs which also contain TDP-43 (Buchan et al., 2013; Gwon et al., 2021) and depletion or inhibition of VCP impairs SG formation (Seguin et al., 2014). This evidence concerns the gene VCP and frontotemporal dementia.