Indeed, the ALS/FTD-associated RBPs TDP-43, FUS and hnRNPA1 can all regulate the transcription of autophagy-related genes, with TDP-43 also able to modulate the transcription factor FOXO and FUS to both initiation and maturation of autophagosomes. The gene discussed is HNRNPA1; the disease is amyotrophic lateral sclerosis.