Although in a non-coding genomic region, the sense and antisense repeat RNA can also be translated via an unconventional mechanism into dipeptide-repeat proteins (DPRs) which form protein aggregates in C9orf72-ALS/FTD patient brain and spinal cord (reviewed in Balendra and Isaacs, 2018). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.