TARDBP and amyotrophic lateral sclerosis: The first category of ALS/FTD-linked genes fall into those encoding for RBPs, like TARDBP (Sreedharan et al., 2008), FUS (Vance et al., 2009), hnRNPA1 (Kim et al., 2013), ANXA11 (Smith et al., 2017) and SMN (Blauw et al., 2012), implicated in RNA metabolism (see Table 1).