The products of these genes, such as those belonging to the autophagy machinery, like ubiquilin-2 (gene: UBQLN2) (Deng et al., 2011), optineurin (OPTN) (Maruyama et al., 2010), and p62 (SQSTM1) (Fecto et al., 2011; Rubino et al., 2012), are also identified in both neuronal and glial inclusions in post-mortem ALS/FTD patient tissue from both familial and sporadic cases, and sometimes colocalise with the above mentioned RBPs (Ramesh and Pandey, 2017). This evidence concerns the gene OPTN and amyotrophic lateral sclerosis.