Similarly, mutants of several ALS/FTD-related RBPs, such as FUS and TDP-43, promote the formation of poorly dynamic SGs (Dewey et al., 2011; Baron et al., 2013; Murakami et al., 2015; Patel et al., 2015; Gopal et al., 2017; Ding et al., 2021). This evidence concerns the gene TARDBP and frontotemporal dementia.