OPTN and frontotemporal dementia: The products of these genes, such as those belonging to the autophagy machinery, like ubiquilin-2 (gene: UBQLN2) (Deng et al., 2011), optineurin (OPTN) (Maruyama et al., 2010), and p62 (SQSTM1) (Fecto et al., 2011; Rubino et al., 2012), are also identified in both neuronal and glial inclusions in post-mortem ALS/FTD patient tissue from both familial and sporadic cases, and sometimes colocalise with the above mentioned RBPs (Ramesh and Pandey, 2017).