Indeed, C9orf72-ALS patient cerebellar tissue exhibits an accumulation of symmetrically arginine-methylated proteins (Chitiprolu et al., 2018), suggesting deficient turnover of SGs, and deregulation of autophagy is observed in cell culture and animal models of SMN-associated neurodegeneration (Garcera et al., 2013; Custer and Androphy, 2014). This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.