SQSTM1 and amyotrophic lateral sclerosis: The ALS-associated autophagy receptor p62 is recruited to SGs upon cellular stress (Chitiprolu et al., 2018; Turakhiya et al., 2018); TBK1 (TANK-binding kinase 1; (Cirulli et al., 2015; Freischmidt et al., 2015)) phosphorylates p62 (Pilli et al., 2012; Matsumoto et al., 2015) and another autophagy receptor - optineurin (Matsumoto et al., 2015), which enhances affinity to cargo and promotes selective autophagy of damaged mitochondria or intracellular pathogens (Richter et al., 2016).