CHMP2B and amyotrophic lateral sclerosis: ESCRT-III proteins, including the ALS/FTD-associated protein CHMP2B (charged multivesicular body protein 2B) (Skibinski et al., 2005; Parkinson et al., 2006; Cox et al., 2010), are responsible for the sorting of cargoes and the completion of vesicular formation (Ugbode and West, 2021).